Oh, don't be a fool now. I've already experienced nukes, which were specifically directed towards the city of New Vegas. Something that I simply got rid of, leaving New Vegas protected.
Oh but Mr.House you see, we do not have nukes.. We have Memes! Enough memes to overrun New Vegas! All of your citizens shouting and screaming memes 24/7! And thats not even mentioning our truly secret weapons!